EMISPHER
EMISPHER International Dissemination Conference
on Public Health in the Euro-Mediterranean region
and Consortium meeting
Cairo,
Egypt
19-22 February 2004
Telemedicine Facilitating Premarital Bioinformation
Dr/ Tarek Rashed
Director of Premarriage Checkup
Center
PCC-NIH
Nasser Institute Hospital
For Research And Treatment.
Aimed
Sector
q PCC-NIH receive the checkup cases of:
Youth
of both gender going to be married for full premarital checkup and genetic counseling.
Pregnant
mothers that have a risky pregnancy to get babies with inherited diseases. To do prenatal diagnoses tests..
Couples
had a child with inherited disease for diagnosis and treatment; and do genetic
counseling for assessment of recurrence risk rate in next pregnancy.
Couples
had general health problems that may affect the marriage for advice and treatment.
Our
Aim
Prevention.
Education.
I.
Prevention
General
health.
Endocrinology.
Andrology.
Gynecology.
Laboratory.
Genetic
Counseling.
Genetic
Counseling
q
consanguineous marriage and families with offspring family history of inherited diseases.
1. Premarital
genetic counseling (do a pedigree on 3
levels and determine the possibility of genetic
diseases in the offspring of this marriage and prove it by genetic testing in case of need.
2. Prenatal
diagnosis in risky marriage.
3. Determine
recurrence risk.
4. Diagnosis
and treatment of affected child.
Full
Medical Report
1.
General health.
2.
Reproductive health.
3.
Genetic Counseling.
II. Education
q Communication with youth
Through:
Our
website on the internet.
Websites
Premarriage
Checkup Center
www.premarriage.1hh.com
Egyptian
Pediatric Genetic Society
www.epgs.1hh.com
Education, orientation
and answer the questions of youth by consultants in every branch through our website.
q Symposia
Suzan
Mubark Center for Science
15 November 2001
Mubarak
Public Liberary
18 July 2002
Home
Economic College Helwan Univ.
18 December 2002
Social
Aim
Aim to:
Decrease
the Handicapped Children rate in our country.
Decrease
the rate of divorce in new families that has been reached 34.5%.
Change
the attitude of the community as regard the increased birth rate problem to be quality not quantity.
Change
the attitude of consanguineous marriage in the area.
Change
the bad attitude as female genital circumcision.
Introduction
of sex education that is a dilemma in the area.
Religion
view
Not
sham, go now
History
Pharaohs
papyrus say that Premarital Checkup was an Ancient Egyptian procedure.
Publications
BMJ
Taiwan,
Turkey, Egypt,
Spain, Portugal,
Italy, and Brazil
all have a form of premarital medical examination. China
1-
February - 2003
Premarriage
Checkup in Egypt
In Melbourn
ICG
2003
Human Genetics and Global Healthcare day:
o As regard the impact of HGP on developing countries there was special attention for consanguineous marriage in the
middle east.
HGP
and Arab World
q
Aim:
Prevention.
Treatment.
Obstacles
q
View of IGC Melbourne 3002:
The
deficiency statistics and data is the vital key for this side of the world.
Consanguineous
marriage is a problem contribute to genetic diseases in Arab World.
Deficiency
of facilities.
Genetic
Diseases Around Glob
4000
mono-genetic diseases around world.
100
Syndromes due to Chromosomal abnormalities around the
world.
Karyotyping
diagnose 1/3 of Mental retardation.
Genetic
diseases is the cause of 50% of abortion and 0.1-0.5 of all pregnancies.
Thalassemia
and Hemoglobinopathy
300,000
child born every year with Thalassemia and Hemoglobinopathies around the world.
300,000,000
carrier of the disease with good health around world.
1:7
carrier around world.
7%
of the world population are carrier.
If
one partner of couple is not a carrier we should tell them that this is not a risky marriage.
216,000
affected by sickle cell anemia in Africa.
As
a result of Thalassemia and Hemoglobinopathy
with
repeated blood transfusion
400,000,000
carrier of HBV.
30-80%
of patients with Thalassemia and Hemoglobinopathy infected with HBV & HCV.
Arab
World
q
Studies
Thalassemia
and Hemoglobinopathy
q Oman:
Study
on children below 2 years showed that:
o 10% has Thalassemia.
o 3.8 have Sickle Cell Anemia.
o Most of them due to consanguineous marriage.
Another
study showed that all patients with Hemoglobinopathy was from same tribe.
Europe
q
Screening for Carrier
Thalassemia
Cyprus:
o Incidence of the disease in newly born was 1:250 in 1974.
o Decreased by 95% within 10 years by screening of teenagers for carrier.
Greeks
and Italy:
o decreased by 50%.
Susceptibility
to Chronic Diseases
Autoimmune
diseases.
DM,
HTN, CAD.
20%
of us are carrier of Hypercholesterolemia gene.
Hashimoto
thyroiditis.
Schizophrenia.
CONSANGUINEOUS
MARRIAGE
IN EGYPT
Alexandria 32.8 %
Nubia
60.5 %
Nubia
(Fadetchi) 61.4 %
Nubia
(Kenuzi) 62.0%
Nubia
(Arabs) 69.8 %
All-Nubia 63.6%
All-Egypt (urban) 22.1%
All-Egypt (suburban) 26.8 %
All-Egypt (rural) 39.1%
All-Egypt (1970) 23.2 %
All-Egypt (1983) 29.0 %
CONSANGUINEOUS
MARRIAGE
IN ARAB WORLD
Tunisia
26.9%
Sudan
52.5%
Kuwait
34.3%
Jordan
39.7%
Saudi
Arabia 40.6%
Bahrain
45%
Iraq
53.4%
CONSANGUINEOUS
MARRIAGE
IN WESTERN
q
(Forbidden Rules In North America)
USA
0.1% (Forbidden Rules in 30 States in USA)
Canada
1.5%
q
(Permitted in Europe)
UK
0.4%
France
0.8%
Italy
1.1%
Spain
% 4.1
Turkey
21.2%
Egyptian
Statistics
q Egyptian
National Research Center
Consanguineous
marriage in Egypt 36.8%.
Autosomal
dominant diseases 13.4%.
Autosomal
recessive diseases 33.6%.
X-linked
diseases 6.7%.
Chromosomal
syndromes 3.4%
Polygenic
and environmental 46.4%.
Congenital
anomaly 20%.
American
Society
For Genetic Counselor
q
Genetic diseases risk factor in families without family history of genetic diseases
Non
consanguineous marriage 2.5%.
Consanguineous
marriage 5-6%.
Significance of Telemedicine
Communication with youth through our website on the internet for answering there questions as regard healthy marriage
and bio-information.
www.premarriage .1hh.com
Propagation for the idea of premarital checkup between youth in Egyptian community.
Marketing for the center service.
Communication and transfer of information between similar centers in Egypt
and around the world.
Communication with research centers as regard clinical genetics and counseling around the globe for share projects.
Genetic counseling facilitation between the center and the primary care unites in the country side to give hand.
As 99.9% of our genome is the same,
Genome suggest that
we are one nation,
But
Communication and Telemedicine
do it.